I spent a week testing over 20 Saturn titles on a PS Vita 2000 (Slim) running Enso 3.65. Here is the realistic tier list.
Developer resource — Yabause / Kronos and Mednafen dev docs (emulator source comments & wiki)
While you can technically install a via RetroArch, it remains a "proof of concept" rather than a viable way to play the library. For now, the Saturn remains the only major 32-bit console that the Vita cannot comfortably conquer.
: For a smooth Saturn experience, modern devices like the Legion Go or dedicated handhelds using the Raspberry Pi 5 are recommended instead. Why Is It So Difficult?
If you are looking to play Sega games on your Vita, other systems from the same era or brand are fully supported:
Even 2D games, which theoretically should be easier, often suffer from major audio distortion, graphical glitches, or failure to boot.