If you are analyzing large molecules or late-eluting peaks with broad shapes, switch your response time to 2.0 seconds or higher. This reduces electrical noise without sacrificing peak shape. The manual explains how to change it; the "better" part is knowing when to change it.
: If peak retention times are correct but intensity is low, perform a wavelength calibration using the built-in holmium oxide filter check. Resource Links shimadzu spd20a user manual better