Launching the game from an external USB drive has been known to cause file-read failures that are resolved by moving the game to an internal SSD. Recommended Fixes Verify Integrity of Game Files: Open your Steam Library and right-click Resident Evil 6 .

Right-click it, select , and go to the Compatibility tab.

Open config.ini and manually change the resolution to a lower setting, turn off , and disable Fullscreen . Save and set the file to "Read-only" if it continues to reset. Update Hardware Drivers:

If you see uPl00 or uPl01 (Leon), uPl02 (Chris), uPl03 (Jake), the error is character-specific. Switch to a different campaign to see if the crash follows you.