In this reality, Itsuki is the only male who remains "healthy". To avoid being captured by the government and used as a biological test subject, he attempts to hide his condition by transferring to a specialized academy. However, the school is populated almost entirely by women—roughly 90% female—making it nearly impossible for him to keep his secret as he is pursued by classmates and teachers alike.

What sets "Modaete Yo Adam-kun" apart from other romantic comedies is its darkly comedic tone. The series doesn't take itself too seriously, often breaking the fourth wall and poking fun at traditional anime and manga tropes. The characters are flawed and relatable, with Aoki being a particularly endearing protagonist. Her sarcastic wit and deadpan reactions to the absurd situations she finds herself in make her a joy to watch.

A polarizing yet integral aspect of the series is the recurring theme of infantilization. Due to his condition, Adam is often treated like a child—held, comforted, and nursed. This appeals to a specific subset of romantic fantasy often overlooked in mainstream shonen romance: the desire to be nurtured.