The story follows Priest (Paul Bettany), a legendary vampire hunter who lives in quiet exile. When his niece (Lily Collins) is kidnapped by a vicious vampire pack, and the Church refuses to act, Priest defies orders. He teams up with his niece’s boyfriend, a rookie sheriff named Hicks (Cam Gigandet), and a rogue Priestess (Maggie Q) to venture into the barren, monster-infested Wasteland. Their goal: rescue the girl and destroy the mutant vampire leader known as the Black Hat (Karl Urban).
The film throws us into an alternate reality where centuries of war between humans and vampires have ended. The Vampire Wars are over, and the legendary Priests—warrior clergy who fought with razor-sharp crucifixes and martial arts—have been disbanded and relegated to the slums.